​GIANLUCA BALDANZI

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Gianluca Baldanzi Works on signal transduction with a specific interest in the biological role of lipid kinases in immune cell function and cell transformation.

-Involvement of DGKα in XLP-1 and WAS primary immunodeficiencies, focusing on its role in T lymphocyte signalling and its regulation by the SAP–WASp signaling pathway.

-Development of a new class of DGKs inhibitors in view of therapeutic use.

-Phosphatidic acid regulated proteins and pathways downstream to DGKs and PLDs. Involvement of phosphatidic acid regulated proteins in signaling of lymphocytes and transformed cells.

-Control of DGKs activity and their role in cell transformation.  Study of tyrosine kinase and second messenger signaling regulating lipid kinase activity in transformed cells with a specific focus on DGKα role in cell survival, immune evasion and angiogenesis.

Past research activities: i) Signalling pathways promoting hepatocyte survival in preconditioned liver; ii) anti-apoptotic and pro-differentiative proprieties of Ghrelin; iii) lipidomic and peptidomic studies on COVID-19 patients.

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